Therapy Detail
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| Therapy Name | CGI1746 |
| Synonyms | |
| Therapy Description |
CGI1746 binds to BTK and prevents its activation, resulting in decreased proliferation of B-cells (PMID: 21113169, PMID: 31234030, PMID: 28915637). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CGI1746 | CGI-1746 | BTK inhibitor 39 | CGI1746 binds to BTK and prevents its activation, resulting in decreased proliferation of B-cells (PMID: 21113169, PMID: 31234030, PMID: 28915637). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK T474I BTK C481S | Advanced Solid Tumor | predicted - resistant | CGI1746 | Preclinical - Biochemical | Actionable | In a preclinical study, treatment with CGI1746 failed to inhibit Btk activity in a cell line expressing BTK variants T474I and C481S in culture (PMID: 33526860). | 33526860 |
| BTK T474M BTK C481S | Advanced Solid Tumor | predicted - resistant | CGI1746 | Preclinical - Biochemical | Actionable | In a preclinical study, treatment with CGI1746 failed to inhibit Btk activity in a cell line expressing BTK variants T474M and C481S in culture (PMID: 33526860). | 33526860 |
| BTK T474M BTK C481T | Advanced Solid Tumor | predicted - resistant | CGI1746 | Preclinical - Biochemical | Actionable | In a preclinical study, treatment with CGI1746 failed to inhibit Btk activity in a cell line expressing BTK variants T474M and C481T in culture (PMID: 33526860). | 33526860 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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