Therapy Detail
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| Therapy Name | Emactuzumab |
| Synonyms | |
| Therapy Description |
Emactuzumab (RG7155) is a monoclonal antibody that inhibits dimerization of CSF1R, resulting in decreased ligand-dependent and ligand-independent signaling, thereby potentially leading to reduced tumor growth (PMID: 24898549, PMID: 32575160, PMID: 31114846). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Emactuzumab | RG7155|RO5509554 | CSF1R Inhibitor 28 | Emactuzumab (RG7155) is a monoclonal antibody that inhibits dimerization of CSF1R, resulting in decreased ligand-dependent and ligand-independent signaling, thereby potentially leading to reduced tumor growth (PMID: 24898549, PMID: 32575160, PMID: 31114846). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05417789 | Phase III | Emactuzumab | Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT) (TANGENT) | Active, not recruiting | USA | SWE | NLD | ITA | GBR | FRA | ESP | CHE | CAN | BEL | AUT | 2 |
| NCT01494688 | Phase I | Emactuzumab Emactuzumab + Paclitaxel | A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Patients With Advanced Solid Tumors | Completed | USA | FRA | 0 |
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