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Therapy Name Ketoconazole
Synonyms
Therapy Description

Ketoconazole is an anti-fungal agent that has been demonstrated to inhibit CYP17, resulting in decreased androgen production (PMID: 21092758).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ketoconazole Nizoral Xolegel|KCZ Ketoconazole is an anti-fungal agent that has been demonstrated to inhibit CYP17, resulting in decreased androgen production (PMID: 21092758).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00536991 Phase Ib/II Prednisone Calcitriol Ketoconazole Calcitriol, Ketoconazole, and Hydrocortisone in Treating Patients With Advanced or Recurrent Prostate Cancer Terminated USA 0
NCT02163356 Phase I Vincristine Sulfate Fenretinide Ketoconazole Fenretinide Lym-X-Sorb + Ketoconazole + Vincristine for Recurrent or Resistant Neuroblastoma Terminated USA 0
NCT03763396 Phase I Posaconazole Ketoconazole Azoles Targeting Recurrent High Grade Gliomas Not yet recruiting CAN 0
NCT02075177 Phase I Ketoconazole Fenretinide Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma No longer available USA 0
NCT01535157 Phase Ib/II Ketoconazole Fenretinide Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Terminated USA 0
NCT02494713 Phase II Degarelix Estramustine Docetaxel Doxorubicin Ketoconazole Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer Terminated USA 0
NCT04869449 Phase I Ketoconazole Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas Recruiting USA 0
NCT00859781 Phase II Prednisone Ketoconazole 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer Active, not recruiting USA 0
NCT03796273 Phase I Ketoconazole Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases Terminated USA 0


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