Therapy Detail
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| Therapy Name | Ketoconazole |
| Synonyms | |
| Therapy Description |
Ketoconazole is an anti-fungal agent that has been demonstrated to inhibit CYP17, resulting in decreased androgen production (PMID: 21092758). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Ketoconazole | Nizoral | Xolegel|KCZ | Ketoconazole is an anti-fungal agent that has been demonstrated to inhibit CYP17, resulting in decreased androgen production (PMID: 21092758). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT00859781 | Phase II | Prednisone Ketoconazole | 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer | Active, not recruiting | USA | 0 |
| NCT03763396 | Phase I | Posaconazole Ketoconazole | Azoles Targeting Recurrent High Grade Gliomas | Not yet recruiting | CAN | 0 |
| NCT02163356 | Phase I | Vincristine Sulfate Fenretinide Ketoconazole | Fenretinide Lym-X-Sorb + Ketoconazole + Vincristine for Recurrent or Resistant Neuroblastoma | Terminated | USA | 0 |
| NCT04869449 | Phase I | Ketoconazole | Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas | Terminated | USA | 0 |
| NCT02494713 | Phase II | Degarelix Estramustine Docetaxel Doxorubicin Ketoconazole | Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer | Terminated | USA | 0 |
| NCT02075177 | Phase I | Ketoconazole Fenretinide | Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma | No longer available | USA | 0 |
| NCT03796273 | Phase I | Ketoconazole | Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases | Terminated | USA | 0 |
| NCT00536991 | Phase Ib/II | Prednisone Calcitriol Ketoconazole | Calcitriol, Ketoconazole, and Hydrocortisone in Treating Patients With Advanced or Recurrent Prostate Cancer | Terminated | USA | 0 |
| NCT01535157 | Phase Ib/II | Ketoconazole Fenretinide | Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer | Terminated | USA | 0 |
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