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Therapy Name ABBV-221
Synonyms
Therapy Description

ABBV-221 (Losatuxizumab vedotin) is an antibody-drug conjugate (ADC) that consists of a monoclonal EGFR antibody and a cytotoxic molecule, MMAE, potentially resulting in anti-tumor activity against EGFR-expressing tumors (PMID: 29483208, PMID: 32189093).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABBV-221 Losatuxizumab vedotin EGFR Antibody 60 ABBV-221 (Losatuxizumab vedotin) is an antibody-drug conjugate (ADC) that consists of a monoclonal EGFR antibody and a cytotoxic molecule, MMAE, potentially resulting in anti-tumor activity against EGFR-expressing tumors (PMID: 29483208, PMID: 32189093).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02365662 Phase I ABBV-221 A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely to Exhibit Elevated Levels of Epidermal Growth Factor Receptor Terminated USA | ESP 0


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