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Therapy Name Aldoxorubicin + Docetaxel + Estramustine + Ketoconazole
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Aldoxorubicin INNO-206|Doxorubicin-EMCH Chemotherapy - Anthracycline 13 Aldoxorubicin (Doxorubicin-EMCH) is a derivative prodrug of doxorubicin that is converted to free doxorubicin within the acidic environment within tumors, and once converted, doxorubicin intercalates DNA, inhibits DNA synthesis and induces apoptosis (PMID: 30936721).
Docetaxel Taxotere RP56976 Antimicrotubule Agent 14 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558).
Estramustine Emcyt Estramustin Sodium Phosphate
Ketoconazole Nizoral Xolegel|KCZ Ketoconazole is an anti-fungal agent that has been demonstrated to inhibit CYP17, resulting in decreased androgen production (PMID: 21092758).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02560051 Phase II Degarelix Aldoxorubicin + Docetaxel + Estramustine + Ketoconazole Hormone Therapy Plus Chemotherapy as Initial Treatment for Local Failures or Advanced Prostate Cancer Terminated USA 0


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