Therapy Detail
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| Therapy Name | BMS-936559 |
| Synonyms | |
| Therapy Description |
BMS-936559 (MDX-1105) is a PD-1 (PDCD1) human monoclonal antibody, which blocks the binding of PD-L1 (CD274) resulting in a T-cell mediated immune response and possible tumor regression (PMID: 22658128, PMID: 30747773). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS-936559 | MDX-1105|BMS936559|BMS 936559 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 134 | BMS-936559 (MDX-1105) is a PD-1 (PDCD1) human monoclonal antibody, which blocks the binding of PD-L1 (CD274) resulting in a T-cell mediated immune response and possible tumor regression (PMID: 22658128, PMID: 30747773). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | malignant spindle cell melanoma | predicted - sensitive | BMS-936559 | Clinical Study - Cohort | Actionable | In a retrospective analysis, PD-1 blockade therapies including Keytruda (pembrolizumab), Opdivo (nivolumab), and BMS-936559 (alone or in combination) resulted in complete response in 32% (19/60), and partial response in 38% (23/60) of malignant spindle cell melanoma patients, whose tumors contained a high percentage of CD274-positive cells (PMID: 29320474). | 29320474 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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