Therapy Detail
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| Therapy Name | Camptothecin + Gedatolisib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Camptothecin | 21,22-Secocamptothecin-21-oic acid lactone|Camptothecine | TOPO1 inhibitor 11 | Camptothecin is a natural product alkaloid topoisomerase I inhibitor from which irinotecan and topotecan are derived (PMID: 16990856, PMID: 32585151) | |
| Gedatolisib | Revtorpyk | PKI-587|PF-05212384|PF 05212384 | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 43 | Revtorpyk (gedatolisib) is an ATP-competitive inhibitor that targets phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, and may result in antitumor activity, including inhibition of tumor growth and tumor regression (PMID: 21325073, PMID: 31822716). Revtorpyk (gedatolisib) is FDA-approved for use in combination with Faslodex (fulvestrant), with or without Ibrance (palbociclib) in patients with hormone receptor-positive, ERBB2 (HER2)-negative locally advanced or metastatic breast cancer without a PIK3CA mutation (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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