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Therapy Name PF-06755990 + PF-06755992 + Sunitinib + Tremelimumab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PF-06755990 PF06755990|PF 06755990 PF-06755990 is cancer vaccine being developed for use in combination with the antiangiogenic therapy, Sunitinib (PMID: 29508855).
PF-06755992 PF 06755992|PF06755992 PF-06755992 is a cancer vaccine consisting of a AdC68 adenovirus engineered to express prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), and prostate stem cell antigen (PSCA), which may result in the induction of cytotoxic T-lymphocyte (CTL) response against PSA, PSMA, PSCA-expressing tumor cells and tumor cell killing (NCI Thesaurus).
Sunitinib Sutent SU011248 CSF1R Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 53 VEGFR2 Inhibitor 37 Sutent (sunitinib) inhibits KDR (VEGFR2), PDGFR, c-KIT, FLT3, RET, and CSF1R, thereby inhibiting angiogenesis and cell proliferation (PMID: 25085632). Sutent (sunitinib) is approved for neuroendocrine tumors of the pancreas, advanced renal cell carcinoma, and GIST (FDA.gov).
Tremelimumab Imjudo CP-675,206|Ticilimumab|CP-675206 CTLA4 Antibody 31 Immune Checkpoint Inhibitor 149 Imjudo (tremelimumab) binds to and inhibits cytotoxic T-lymphocyte-associated protein 4 (CTLA4), thereby enhancing T-cell activation by blocking CTLA4-mediated inhibition of T-cell activation (PMID: 32620213, PMID: 32586937). Imjudo (tremelimumab) is FDA approved for use in combination with Imfinzi (durvalumab) in adult patients with unresectable hepatocellular carcinoma, and in combination with Imfinzi (durvalumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02616185 Phase I PF-06755990 + PF-06755992 + Sunitinib + Tremelimumab A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR) Terminated USA 0


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