Therapy Detail
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| Therapy Name | HMPL-453 |
| Synonyms | |
| Therapy Description |
HMPL-453 binds and inhibits FGFR -1, -2, and -3, which may result in the inhibition of FGFR mediated signal transduction pathways and inhibition of tumor cell proliferation (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HMPL-453 | HMPL453|HMPL 453 | FGFR Inhibitor (Pan) 26 | HMPL-453 binds and inhibits FGFR -1, -2, and -3, which may result in the inhibition of FGFR mediated signal transduction pathways and inhibition of tumor cell proliferation (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 fusion | intrahepatic cholangiocarcinoma | predicted - sensitive | HMPL-453 | Phase II | Actionable | In a Phase II trial, HMPL-453 treatment demonstrated acceptable toxicity in patients with advanced intrahepatic cholangiocarcinoma harboring FGFR2 fusions, and resulted in an overall response rate of 31.8% (7/22, all partial responses) and disease control rate (DCR) of 86.4% (19/22), with stable disease in 12 patients, with an objective response rate of 50% and DCR of 90% at a dose of 300mg (n=10) (J Clin Oncol 41, 2023 (suppl 16; abstr e16118); NCT04353375). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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