Therapy Detail
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| Therapy Name | 5-Fluoro-2-deoxycytidine + Tetrahydrouridine |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 5-Fluoro-2-deoxycytidine | FdCyd|RO-5-1090 | 5-Fluoro-2-deoxycytidine (FdCyd) is a fluorinated pyrimidine analogue that is metabolized to 5-fluorouracil (5-FU) intercellularly, which is cytotoxic (PMID: 17899082). | ||
| Tetrahydrouridine | THU | Tetrahydrouridine is a synthetic pyrimidine analogue that inhibits deoxycytidine monophosphate (dCMP) deaminase, which in turn inhibits cell proliferation (PMID: 22616006, PMID: 32314030). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01534598 | Phase I | 5-Fluoro-2-deoxycytidine + Tetrahydrouridine | FdCyd and THU for Advanced Solid Tumors | Completed | USA | 0 |
| NCT00978250 | Phase II | 5-Fluoro-2-deoxycytidine + Tetrahydrouridine | A Multi-Histology Phase II Study of 5-Fluoro-2-Deoxycytidine With Tetrahydrouridine (FdCyd + THU) | Completed | USA | 0 |
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