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Therapy Name Rosmantuzumab
Synonyms
Therapy Description

Rosmantuzumab (OMP-131R10) is a monoclonal antibody that targets R-spondin 3 (RSPO3), which results in decreased pathway activation and may lead to reduced tumor cell proliferation and decreased survival of cancer stem cells (PMID: 32559496).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Rosmantuzumab OMP-131R10 WNT Inhibitor 16 Rosmantuzumab (OMP-131R10) is a monoclonal antibody that targets R-spondin 3 (RSPO3), which results in decreased pathway activation and may lead to reduced tumor cell proliferation and decreased survival of cancer stem cells (PMID: 32559496).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02482441 Phase I Rosmantuzumab Fluorouracil + Irinotecan + Leucovorin A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10 Completed USA 0


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