Therapy Detail
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| Therapy Name | anti-thymocyte globulin + BKT140 + Cyclosporine + Methylprednisolone |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BKT140 | TN14003|BL-8040|BL8040|Motixafortide | CXCR4 Inhibitor 15 | BL-8040 (BKT140) is a selective CXCR4 antagonist that prevents SDF-1 (CXCL12) binding, which may lead to decreased tumor growth (PMID: 21138752). | |
| Cyclosporine | Sandimmune | Ciclosporin | ||
| Methylprednisolone | Artisone-Wyeth | 6alpha-Methylprednisolone | ||
| anti-thymocyte globulin | Thymoglobulin | lymphocyte immune globulin|ATGAM | Thymoglobulin (anti-thymocyte globulin) is an immunoglobulin that binds to and destroys T-lymphocytes, which may aid in reduction of graft-vs-host disease when administered with stem cell transplantation (PMID: 32624582). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02462252 | Phase II | anti-thymocyte globulin + BKT140 + Cyclosporine + Methylprednisolone | Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome | Completed | USA | 0 |
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