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Therapy Name Disitamab vedotin
Synonyms
Therapy Description

Disitamab vedotin (RC48) is an antibody-drug conjugate comprising a monoclonal antibody that targets HER2 (Hertuzumab) linked to the cytotoxic drug MMAE, which delivers the cytotoxic agent to HER2-expressing tumor cells, potentially resulting in increased cell death (PMID: 27509865, PMID: 31877330).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Disitamab vedotin RC48|Hertuzumab-vc-MMAE|RC-48 HER2 (ERBB2) Antibody 76 Disitamab vedotin (RC48) is an antibody-drug conjugate comprising a monoclonal antibody that targets HER2 (Hertuzumab) linked to the cytotoxic drug MMAE, which delivers the cytotoxic agent to HER2-expressing tumor cells, potentially resulting in increased cell death (PMID: 27509865, PMID: 31877330).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04879329 Phase II Disitamab vedotin Disitamab vedotin + Pembrolizumab A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2 Recruiting USA | ITA | ISR | GBR | ESP | CAN | BEL | AUS | ARG 2
NCT06003231 Phase II Disitamab vedotin A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2 Recruiting USA | ITA | GBR | ESP | CAN | AUS 1
NCT06157892 Phase Ib/II Disitamab vedotin + Tucatinib Disitamab vedotin A Study of Disitamab Vedotin Alone or With Other Anticancer Drugs in Solid Tumors Recruiting USA | ITA | GBR | ESP | CAN | AUS 1


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