Therapy Detail
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| Therapy Name | AZD8055 + Fexagratinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD8055 | AZD-8055 | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42 | AZD8055 is a PI3K/MTOR inhibitor that reduces downstream signaling, resulting in decreased tumor cell growth (PMID: 20028854, PMID: 31519159). | |
| Fexagratinib | AZD-4547|AZD4547|AZD 4547|ABSK091|KB-74810|ABSK 091|ABSK-091|KB74810|KB 74810 | FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19 | Fexagratinib selectively binds and inhibits FGFR1, 2, and 3, which may result in the inhibition of FGFR-mediated signal transduction pathways and inhibition of tumor cell proliferation (PMID: 22369928, PMID: 30115694, PMID: 32463741), and has demonstrated inhibitory effects on NTRK signaling (PMID: 34790577). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 positive | lung large cell carcinoma | sensitive | AZD8055 + Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, AZD4547 and AZD8055 synergistically inhibited survival of FGFR1-dependent lung large cell carcinoma cells in culture (PMID: 26359452). | 26359452 |
| FGFR1 positive | lung adenocarcinoma | sensitive | AZD8055 + Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, AZD4547 and AZD8055 synergistically inhibited survival of FGFR1-dependent lung adenocarcinoma cells in culture (PMID: 26359452). | 26359452 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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