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Therapy Name	Conteltinib
Synonyms
Therapy Description	Conteltinib (CT-707) is a kinase inhibitor of FAK (PTK2), PYK2 (PTK2B), ALK, and YAP1 (PMID: 29669759), which may result in antitumor activity including inhibition of both tumor growth and metastasis (PMID: 27638856, PMID: 30381078).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Conteltinib		CT-707\|CT 707	ALK Inhibitor 33 FAK inhibitor 16 YAP Inhibitor 3	Conteltinib (CT-707) is a kinase inhibitor of FAK (PTK2), PYK2 (PTK2B), ALK, and YAP1 (PMID: 29669759), which may result in antitumor activity including inhibition of both tumor growth and metastasis (PMID: 27638856, PMID: 30381078).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ALK rearrange	lung adenocarcinoma	predicted - sensitive	Conteltinib	Phase I	Actionable	In a Phase I trial, Conteltinib (CT-707) demonstrated safety and preliminary efficacy, resulting in an overall response rate of 77% (10/13, 1 complete response, 9 partial responses) and a disease control rate of 85% (11/13) in patients with ALK-rearranged lung adenocarcinoma (n=12) or malignant pleural mesothelioma (n=1), median progression-free survival was 13 months in patients with lung adenocarcinoma (PMID: 32181989).	32181989
ALK rearrange	lung non-small cell carcinoma	sensitive	Conteltinib	Phase I	Actionable	In a Phase I trial, Conteltinib (CT-707) demonstrated safety and efficacy in patients with ALK-positive non-small cell lung cancer, resulting in an overall response rate (ORR) of 53.3% (32/60), a disease control rate (DCR) of 80%, and a median progression-free survival of 9.26 months, with an ORR of 61.4% (25/39) and a DCR of 82.1% in ALK inhibitor-naive patients and an ORR of 33.3% (7/21) and a DCR of 76.2% (16/21) in patients previously treated with Xalkori (crizotinib) (PMID: 36424628; NCT02695550).	36424628
ALK rearrange	malignant pleural mesothelioma	no benefit	Conteltinib	Case Reports/Case Series	Actionable	In a Phase I trial, Conteltinib (CT-707) treatment resulted in disease progression after 1 cycle in a patient with ALK-rearranged malignant pleural mesothelioma (PMID: 32181989).	32181989
ALK F1174L	Advanced Solid Tumor	predicted - sensitive	Conteltinib	Preclinical - Biochemical	Actionable	In a preclinical study, Conteltinib (CT-707) inhibited ALK F1174L activity in an in vitro assay (PMID: 36424628).	36424628
ALK G1202R	Advanced Solid Tumor	predicted - sensitive	Conteltinib	Preclinical - Biochemical	Actionable	In a preclinical study, Conteltinib (CT-707) inhibited ALK G1202R activity in an in vitro assay (PMID: 36424628).	36424628
ALK G1269S	Advanced Solid Tumor	predicted - sensitive	Conteltinib	Preclinical - Biochemical	Actionable	In a preclinical study, Conteltinib (CT-707) inhibited ALK G1269S activity in an in vitro assay (PMID: 36424628).	36424628
ALK L1196M	Advanced Solid Tumor	predicted - sensitive	Conteltinib	Preclinical - Biochemical	Actionable	In a preclinical study, Conteltinib (CT-707) inhibited ALK L1196M activity in an in vitro assay (PMID: 36424628).	36424628
ALK R1275Q	Advanced Solid Tumor	predicted - sensitive	Conteltinib	Preclinical - Biochemical	Actionable	In a preclinical study, Conteltinib (CT-707) inhibited ALK R1275Q activity in an in vitro assay (PMID: 36424628).	36424628

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