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Therapy Name Afimoxifene
Synonyms
Therapy Description

Afimoxifene (4-hydroxy-tamoxifen) is a metabolite of tamoxifen, which binds to the estrogen receptor and acts as an antagonist in tumor cells (PMID: 32019136).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Afimoxifene 4-Hydroxy-Tamoxifen|4-hydroxytamoxifen|Hydroxytamoxifen Hormone - Anti-estrogens 31 Afimoxifene (4-hydroxy-tamoxifen) is a metabolite of tamoxifen, which binds to the estrogen receptor and acts as an antagonist in tumor cells (PMID: 32019136).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02993159 Phase II Afimoxifene Tamoxifen Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast Completed USA 0
NCT04009044 Phase II Afimoxifene Topical Afimoxifene in Treating Patients With Breast Cancer Who Have Undergone Radiation Therapy on One Breast Active, not recruiting USA 0


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