Therapy Detail
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| Therapy Name | HER2-pulsed DC1 vaccine |
| Synonyms | |
| Therapy Description |
HER2-pulsed DC1 vaccine is a cancer vaccine comprising patient-derived dendritic cells exposed to ERBB2 (HER2)-derived peptides, which potentially enhances anti-tumor immune response against ERBB2 (HER2)-expressing tumor cells (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HER2-pulsed DC1 vaccine | HER2-pulsed type-1 polarized autologous dendritic cell vaccine | HER2 (ERBB2) Vaccine 14 | HER2-pulsed DC1 vaccine is a cancer vaccine comprising patient-derived dendritic cells exposed to ERBB2 (HER2)-derived peptides, which potentially enhances anti-tumor immune response against ERBB2 (HER2)-expressing tumor cells (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03387553 | Phase I | HER2-pulsed DC1 vaccine | HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer | Active, not recruiting | USA | 0 |
| NCT02336984 | Phase Ib/II | Trastuzumab HER2-pulsed DC1 vaccine | A Phase I/II Trial of HER-2/Neu Pulsed DC1 Vaccine Combined With Trastuzumab for Patients With DCIS | Withdrawn | USA | 0 |
| NCT05378464 | Phase I | Pepinemab + Trastuzumab HER2-pulsed DC1 vaccine | Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine & Pepinemab /Trastuzumab in Patients w/ Metastatic HER2+ Breast Cancer | Recruiting | USA | 0 |
| NCT05504707 | Phase I | HER2-pulsed DC1 vaccine HER3-primed DC1 vaccine | DecipHER Trial - DC1 Tx for Early-Stage TNBC and ER Low Positive Breast Cancer (DecipHER) | Recruiting | USA | 0 |
| NCT02061332 | Phase Ib/II | HER2-pulsed DC1 vaccine | DC Vaccine for Patients With Ductal Carcinoma In Situ | Completed | USA | 0 |
| NCT03630809 | Phase II | HER2-pulsed DC1 vaccine | Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1 | Terminated | USA | 0 |
| NCT03384914 | Phase II | HER2-pulsed DC1 vaccine pUMVC3-IGFBP2-HER2-IGF1R vaccine | Vaccine to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer | Active, not recruiting | USA | 0 |
| NCT02063724 | Phase I | HER2-pulsed DC1 vaccine | HER-2 Pulsed DC Vaccine to Prevent Recurrence of Invasive Breast Cancer (Adjuvant) | Completed | USA | 0 |
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