Therapy Detail
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| Therapy Name | Apalutamide + Degarelix |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Apalutamide | Erleada | ARN-509|JNJ-56021927 | Hormone - Anti-androgens 54 | Erleada (apalutamide) is a second-generation antiandgrogen, that binds to the androgen receptor (AR) and inhibits downstream signaling, potentially resulting in decreased growth of AR-expressing tumors (PMID: 22266222, PMID: 23337756). Erleada (apalutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer (FDA.gov). |
| Degarelix | Firmagon | FE200486 |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03009981 | Phase III | Abiraterone + Apalutamide + Degarelix + Prednisone Apalutamide + Degarelix Degarelix | A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer | Active, not recruiting | USA | 0 |
| NCT03080116 | Phase II | Degarelix Apalutamide + Degarelix | Neoadjuvant Degarelix With or Without Apalutamide (ARN-509) Followed by Radical Prostatectomy (ARNEO) | Active, not recruiting | BEL | 0 |
| NCT04585932 | Phase II | Apalutamide + Degarelix Apalutamide + Leuprolide | Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study | Withdrawn | USA | 0 |
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