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Therapy Detail
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| Therapy Name | Talacotuzumab |
| Synonyms | |
| Therapy Description |
Talacotuzumab (JNJ-56022473) is a monoclonal antibody directed against CD123 (IL3RA), which may increase antibody-dependent cell-mediated cytoxicity of CD123 (IL3RA)-expressing tumor cells (Blood Dec 2015, 126 (23) 4946). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Talacotuzumab | JNJ-56022473|CSL362|JNJ-473 | Talacotuzumab (JNJ-56022473) is a monoclonal antibody directed against CD123 (IL3RA), which may increase antibody-dependent cell-mediated cytoxicity of CD123 (IL3RA)-expressing tumor cells (Blood Dec 2015, 126 (23) 4946). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03011034 | Phase II | Talacotuzumab Daratumumab | Study to Separately Evaluate the Activity of Talacotuzumab (JNJ-56022473) or Daratumumab in Transfusion-Dependent Participants With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) Who Are Relapsed or Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment | Completed | USA | NLD | ITA | ESP | BEL | 1 |
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