Therapy Detail
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| Therapy Name | Aumolertinib |
| Synonyms | |
| Therapy Description |
Aumolertinib (HS-10296) is a third-generation small molecule inhibitor of EGFR activating mutations and EGFR T790M (PMID: 28149837, PMID: 32895156). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Aumolertinib | HS-10296||HS10296|Almonertinib | EGFR Inhibitor 3rd gen 26 | Aumolertinib (HS-10296) is a third-generation small molecule inhibitor of EGFR activating mutations and EGFR T790M (PMID: 28149837, PMID: 32895156). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05493501 | Phase III | Aumolertinib + Cisplatin + Pemetrexed Disodium Aumolertinib + Carboplatin + Pemetrexed Disodium Aumolertinib + Carboplatin + Paclitaxel Aumolertinib + Cisplatin + Paclitaxel Aumolertinib + Cisplatin + Nab-paclitaxel Aumolertinib + Carboplatin + Nab-paclitaxel Aumolertinib + Cisplatin + Gemcitabine Aumolertinib Aumolertinib + Carboplatin + Gemcitabine Osimertinib | Aumolertinib With Chemotherapy or Alone Compared With Osimertinib in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer | Terminated | USA | 0 |
| NCT02981108 | Phase Ib/II | Aumolertinib | A Study to Evaluate Safety, PK and Efficacy of HS-10296 in Patients With NSCLC | Active, not recruiting | USA | 0 |
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