Therapy Detail
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| Therapy Name | Letetresgene autoleucel |
| Synonyms | |
| Therapy Description |
Letetresgene autoleucel (GSK3377794) are autologous T-cells engineered to express a T-cell receptor that recognizes the cancer testis antigen, CTAG1B (NY-ESO-1), which may induce an immune response against CTAG1B and/or CTAG2 (LAGE-1)-expressing cancer cells (PMID: 26193344, PMID: 36075914). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Letetresgene autoleucel | GSK3377794|GSK-3377794|GSK 3377794|NY-ESO-1-c259T | Letetresgene autoleucel (GSK3377794) are autologous T-cells engineered to express a T-cell receptor that recognizes the cancer testis antigen, CTAG1B (NY-ESO-1), which may induce an immune response against CTAG1B and/or CTAG2 (LAGE-1)-expressing cancer cells (PMID: 26193344, PMID: 36075914). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03709706 | Phase Ib/II | Letetresgene autoleucel + Pembrolizumab Letetresgene autoleucel | Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel, GSK3377794)T-cells in New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab | Terminated | USA | NLD | GBR | ESP | CAN | 0 |
| NCT03168438 | Phase II | Letetresgene autoleucel Letetresgene autoleucel + Pembrolizumab | Letetresgene Autoleucel Engineered T Cells Alone and in Combination With Pembrolizumab in NY-ESO-1 Positive Multiple Myeloma | Terminated | USA | 0 |
| NCT02992743 | Phase II | Letetresgene autoleucel | Letetresgene Autoleucel Engineered T Cells in NY-ESO-1 Positive Participants With Advanced Myxoid/ Round Cell Liposarcoma | Completed | USA | 0 |
| NCT01343043 | Phase Ib/II | Letetresgene autoleucel | A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1c259T in HLA-A2+ Patients With Synovial Sarcoma (NY-ESO-1) | Completed | USA | 0 |
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