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Therapy Name CART19 cells
Synonyms
Therapy Description

CART19 cells are allogeneic T lymphocytes engineered to express a CD19-targeted chimeric antigen receptor (CAR) containing a CD3 zeta chain and the TNFRSF9 (4-1BB) signaling domain, which may induce antitumor activity (PMID: 21716851).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CART19 cells CART-19 cells CD19 Immune Cell Therapy 72 CART19 cells are allogeneic T lymphocytes engineered to express a CD19-targeted chimeric antigen receptor (CAR) containing a CD3 zeta chain and the TNFRSF9 (4-1BB) signaling domain, which may induce antitumor activity (PMID: 21716851).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02640209 Phase I CART19 cells Pilot Trial Of Autologous T Cells Engineered To Express Anti-CD19 Chimeric Antigen Receptor (CART19)In Combination With Ibrutinib In Patients With Relapsed Or Refractory CD19+ Chronic Lymphocytic Leukemia (CLL)Or Small Lymphocytic Lymphoma (SLL) Terminated USA 0
NCT02935543 Phase II CART19 cells CART19 in Patient With ALL Terminated USA 0


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