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Therapy Detail
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| Therapy Name | CART19 cells |
| Synonyms | |
| Therapy Description |
CART19 cells are allogeneic T lymphocytes engineered to express a CD19-targeted chimeric antigen receptor (CAR) containing a CD3 zeta chain and the TNFRSF9 (4-1BB) signaling domain, which may induce antitumor activity (PMID: 21716851). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CART19 cells | CART-19 cells | CD19 Immune Cell Therapy 65 | CART19 cells are allogeneic T lymphocytes engineered to express a CD19-targeted chimeric antigen receptor (CAR) containing a CD3 zeta chain and the TNFRSF9 (4-1BB) signaling domain, which may induce antitumor activity (PMID: 21716851). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02935543 | Phase II | CART19 cells | CART19 in Patient With ALL | Terminated | USA | 0 |
| NCT02640209 | Phase I | CART19 cells | Pilot Trial Of Autologous T Cells Engineered To Express Anti-CD19 Chimeric Antigen Receptor (CART19)In Combination With Ibrutinib In Patients With Relapsed Or Refractory CD19+ Chronic Lymphocytic Leukemia (CLL)Or Small Lymphocytic Lymphoma (SLL) | Terminated | USA | 0 |
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