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Therapy Name HER2 CAR-T cells
Synonyms
Therapy Description

HER2 CAR-T cells are T-cells that are modified to express a chimeric antigen receptor recognizing ERBB2 (HER2), which may result in increased death of ERBB2 (HER2)-expressing tumor cells upon infusion (PMID: 25800760, PMID: 25711536).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HER2 CAR-T cells ERBB2 (HER2) CAR-T cells|ERBB2 CAR-T cells HER2 (ERBB2) Immune Cell Therapy 6 HER2 CAR-T cells are T-cells that are modified to express a chimeric antigen receptor recognizing ERBB2 (HER2), which may result in increased death of ERBB2 (HER2)-expressing tumor cells upon infusion (PMID: 25800760, PMID: 25711536).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04903080 Phase I HER2 CAR-T cells HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma Recruiting USA 0
NCT03696030 Phase I HER2 CAR-T cells HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases Recruiting USA 0
NCT03389230 Phase I HER2 CAR-T cells Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma Active, not recruiting USA 0
NCT03500991 Phase I HER2 CAR-T cells HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors Active, not recruiting USA 0


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