Therapy Detail
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| Therapy Name | Camrelizumab |
| Synonyms | |
| Therapy Description |
Camrelizumab (SHR-1210) is an antibody that targets PD-1 (PDCD1) and inhibits binding of PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in activation of anti-tumor immune response and decreased tumor growth (PMID: 29358502, PMID: 32623573, PMID: 32581041). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Camrelizumab | SHR-1210|INCSHR-1210 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | Camrelizumab (SHR-1210) is an antibody that targets PD-1 (PDCD1) and inhibits binding of PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in activation of anti-tumor immune response and decreased tumor growth (PMID: 29358502, PMID: 32623573, PMID: 32581041). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | esophagus squamous cell carcinoma | predicted - sensitive | Camrelizumab | Phase I | Actionable | In a Phase I trial, Camrelizumab (SHR-1210) treatment resulted improved objective response rate (46.7%, 7/15 vs 11.1%, 1/9, p>0.05) and disease control rate (66.7%, 10/15 vs 33.3%, 3/9) in patients with CD274 (PD-L1)-positive advanced esophageal squamous cell carcinoma compared to patients with CD274 (PD-L1)-negative tumors (PMID: 29358502; NCT02742935). | 29358502 |
| CD274 positive | cervical adenocarcinoma | predicted - sensitive | Camrelizumab | Case Reports/Case Series | Actionable | In a clinical case study, Camrelizumab (SHR-1210) treatment resulted in a partial response in the cervical tumor and a complete response in the pulmonary metastases in a patient with CD274 (PD-L1)-positive (IHC = 1%) cervical adenocarcinoma, who previously progressed on chemotherapy treatment (PMID: 35280424). | 35280424 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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