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Therapy Name Odronextamab
Synonyms
Therapy Description

Odronextamab (REGN1979) is a CD20/CD3 bispecific antibody, which targets CD20 expressing cells via T-cell activation, and subsequently leads to cell death (PMID: 26659273).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Odronextamab REGN1979 Odronextamab (REGN1979) is a CD20/CD3 bispecific antibody, which targets CD20 expressing cells via T-cell activation, and subsequently leads to cell death (PMID: 26659273).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07128641 Phase II Odronextamab Odronextamab in Low Tumor Volume Advanced FL Not yet recruiting USA 0
NCT06784726 Phase II Odronextamab Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T Recruiting USA 0
NCT06230224 Phase III Carboplatin + Etoposide + Ifosfamide Carboplatin + Etoposide + Ifosfamide + Rituximab Cisplatin + Dexamethasone + Gemcitabine + Rituximab Cisplatin + Cytarabine + Dexamethasone Cisplatin + Dexamethasone + Gemcitabine Odronextamab Cisplatin + Cytarabine + Dexamethasone + Rituximab A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma (OLYMPIA-4) Recruiting TUR | ROU | NLD | ITA | HUN | ESP | BRA | AUS | ARG 7
NCT02290951 Phase I Rituximab Odronextamab Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies (ELM-1) Completed USA | ISR | GBR | FRA | DEU 0
NCT06854159 Phase II Odronextamab Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy Recruiting USA 0
NCT05991388 Phase II Carboplatin + Dexamethasone + Etoposide + Ifosfamide + Loncastuximab tesirine-lpyl + Rituximab Odronextamab Carboplatin + Dexamethasone + Etoposide + Ifosfamide + Rituximab A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma (Glo-BNHL) Recruiting SWE | NZL | NLD | GBR | BEL | AUT | AUS 0
NCT03888105 Phase II Odronextamab Assess the Anti-Tumor Activity and Safety of REGN1979 in Patients With Relapsed or Refractory Follicular Lymphoma Active, not recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | AUS 5
NCT06097364 Phase III Rituximab Cyclophosphamide + Doxorubicin + Odronextamab + Prednisone + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Odronextamab Cyclophosphamide + Odronextamab + Prednisone + Vincristine Sulfate A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma (OLYMPIA-2) Active, not recruiting USA | TUR | POL | ITA | ISR | GBR | FRA | ESP | DEU | CZE | BRA | BEL | AUT | AUS 3
NCT06091254 Phase III Odronextamab Cyclophosphamide + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Bendamustine + Rituximab A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Follicular Lymphoma (OLYMPIA-1) Active, not recruiting USA | TUR | POL | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS 3


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