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Therapy Detail

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Therapy Name Odronextamab
Synonyms
Therapy Description

Odronextamab (REGN1979) is a CD20/CD3 bispecific antibody, which targets CD20 expressing cells via T-cell activation, and subsequently leads to cell death (PMID: 26659273).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Odronextamab REGN1979 Odronextamab (REGN1979) is a CD20/CD3 bispecific antibody, which targets CD20 expressing cells via T-cell activation, and subsequently leads to cell death (PMID: 26659273).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06097364 Phase III Rituximab Cyclophosphamide + Doxorubicin + Odronextamab + Prednisone + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Odronextamab Cyclophosphamide + Odronextamab + Prednisone + Vincristine Sulfate A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma (OLYMPIA-2) Recruiting USA | TUR | POL | ITA | ISR | GBR | FRA | ESP | CZE | BEL | AUT | AUS 3
NCT05991388 Phase II Carboplatin + Dexamethasone + Etoposide + Ifosfamide + Loncastuximab tesirine-lpyl + Rituximab Odronextamab Carboplatin + Dexamethasone + Etoposide + Ifosfamide + Rituximab A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma (Glo-BNHL) Recruiting GBR 0
NCT06091254 Phase III Odronextamab Cyclophosphamide + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Bendamustine + Rituximab A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Participants With Follicular Lymphoma (OLYMPIA-1) Recruiting USA | TUR | POL | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | AUT | AUS 2
NCT03888105 Phase II Odronextamab Assess the Anti-Tumor Activity and Safety of REGN1979 in Patients With Relapsed or Refractory Follicular Lymphoma Recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | AUS 5
NCT06854159 Phase II Odronextamab Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy Not yet recruiting USA 0
NCT06230224 Phase III Carboplatin + Etoposide + Ifosfamide Carboplatin + Etoposide + Ifosfamide + Rituximab Cisplatin + Dexamethasone + Gemcitabine + Rituximab Cisplatin + Cytarabine + Dexamethasone Cisplatin + Dexamethasone + Gemcitabine Odronextamab Cisplatin + Cytarabine + Dexamethasone + Rituximab A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma (OLYMPIA-4) Recruiting TUR | NLD | ITA | ESP | AUS 5
NCT06784726 Phase II Odronextamab Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T Not yet recruiting USA 0
NCT02290951 Phase I Rituximab Odronextamab Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies (ELM-1) Active, not recruiting USA | ISR | GBR | FRA | DEU 0


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