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Therapy Name | INU-152 |
Synonyms | |
Therapy Description |
INU-152 is a small molecule pan-RAF inhibitor, which reduces downstream MAPK pathway signaling and may inhibit growth of BRAF-mutant tumors (PMID: 28645859). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
INU-152 | RAF Inhibitor (Pan) 28 | INU-152 is a small molecule pan-RAF inhibitor, which reduces downstream MAPK pathway signaling and may inhibit growth of BRAF-mutant tumors (PMID: 28645859). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | colorectal cancer | sensitive | INU-152 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, INU-152 inhibited growth of colorectal cancer cell lines harboring BRAF V600E in culture, and reduced tumor growth in BRAF V600E-mutant colorectal cancer cell line xenograft models (PMID: 28645859). | 28645859 |
BRAF V600E | melanoma | sensitive | INU-152 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, INU-152 reduced MEK and ERK phosphorylation and growth of a melanona cell line harboring BRAF V600E in culture, and inhibited tumor growth in xenograft models (PMID: 28645859). | 28645859 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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