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Therapy Detail
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| Therapy Name | H3B-6527 |
| Synonyms | |
| Therapy Description |
H3B-6527 selectively inhibits FGFR4, resulting in decreased downstream signaling and potentially leading to reduced tumor cell proliferation and tumor growth inhibition (PMID: 29247039, PMID: 31770593). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| H3B-6527 | H3B6527 | FGFR4 Inhibitor 10 | H3B-6527 selectively inhibits FGFR4, resulting in decreased downstream signaling and potentially leading to reduced tumor cell proliferation and tumor growth inhibition (PMID: 29247039, PMID: 31770593). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02834780 | Phase I | H3B-6527 | Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Subjects With Advanced Hepatocellular Carcinoma | Completed | USA | ITA | GBR | FRA | ESP | CAN | BEL | 4 |
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