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Therapy Name MCLA-158
Synonyms
Therapy Description

MCLA-158 is a bispecific antibody that targets EGFR and LGR5, potentially resulting in decreased tumor growth (Cancer Res July 1 2017 (77) (13 Supplement) 32).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MCLA-158 MCLA 158|MCLA158|petosemtamab EGFR Antibody 72 MCLA-158 is a bispecific antibody that targets EGFR and LGR5, potentially resulting in decreased tumor growth (Cancer Res July 1 2017 (77) (13 Supplement) 32).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03526835 Phase I MCLA-158 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors Recruiting USA | NLD | GBR | FRA | ESP | BEL 0
NCT06496178 Phase III Methotrexate Cetuximab Docetaxel MCLA-158 A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients Recruiting USA | POL | NLD | LTU | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CHE | CAN | BRA | BEL | AUS | ARG 4


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