Therapy Detail
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| Therapy Name | BXQ-350 |
| Synonyms | |
| Therapy Description |
SapC-DOPS (BXQ-350) is a nanovesicle of saposin C (SapC; a lysosomal protein) and dioleylphosphatidylserine (DOPS) that targets phosphatidylserine to activate lysosomes resulting in apoptosis in cells with high surface levels of phosphatidylserine (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 2517-2517, PMID: 31918715). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BXQ-350 | SapC-DOPS | SapC-DOPS (BXQ-350) is a nanovesicle of saposin C (SapC; a lysosomal protein) and dioleylphosphatidylserine (DOPS) that targets phosphatidylserine to activate lysosomes resulting in apoptosis in cells with high surface levels of phosphatidylserine (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 2517-2517, PMID: 31918715). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02859857 | Phase I | BXQ-350 | Phase 1 Study of BXQ-350 in Adult Patients With Advanced Solid Tumors | Completed | USA | 0 |
| NCT04404569 | Phase I | BXQ-350 | Continued Treatment for Participants Enrolled in Studies of BXQ-350 | Terminated | USA | 0 |
| NCT05322590 | Phase Ib/II | BXQ-350 | BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma (ASIST) | Active, not recruiting | USA | 0 |
| NCT04771897 | Phase I | BXQ-350 | A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) (KONQUER) | Terminated | USA | 0 |
| NCT03967093 | Phase I | BXQ-350 | A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors | Terminated | USA | 0 |
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