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Therapy Name Cemiplimab + INO-5401 + INO-9012 + Temozolomide
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cemiplimab Libtayo REGN2810|SAR439684 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Libtayo (cemiplimab) is a human antibody that targets PD-1 (PDCD1) and prevents interaction with PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in increased anti-tumor immune response and decreased tumor growth (PMID: 28265006). Libtayo (cemiplimab) is FDA approved for use in patients with cutaneous squamous cell carcinoma, who are not not eligible for curative surgery or radiation, in patients with locally advanced or metastatic basal cell carcinoma who have received or are not eligible for a hedgehog pathway inhibitor, as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC) with high PD-L1 expression (TPS>=50%) and no EGFR, ALK, or ROS1 aberrations, and in combination with platinum-based chemotherapy as first-line treatment for patients with NSCLC without EGFR, ALK, or ROS1 alterations (FDA.gov).
INO-5401 INO5401|INO 5401 INO-5401 is a synthetic DNA immunotherapy that delivers plasmids to express three tumor associated antigens (WT1, PSMA (FOLH1), and TERT), which stimulates the immune system to attack cells expressing these antigens (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT114).
INO-9012 INO9012|INO 9012 INO-9012 is a plasmid encoding IL-12 protein subunits, p35 and p40, which may increase anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT114, PMID: 32208168).
Temozolomide Temodar Methazolastone|TMZ Chemotherapy - Alkylating 18 Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03491683 Phase Ib/II Cemiplimab + INO-5401 + INO-9012 + Temozolomide INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM) Active, not recruiting USA 0


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