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Therapy Name OBI-3424
Synonyms
Therapy Description

OBI-3424 (TH 3424) is an AKR1C3-activated prodrug that is converted to a DNA alkylating agent, resulting in tumor cell death (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-B16, PMID: 31015346).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
OBI-3424 OBI3424|OBI 3424|TH3424|TH 3424|TH-3424 OBI-3424 (TH 3424) is an AKR1C3-activated prodrug that is converted to a DNA alkylating agent, resulting in tumor cell death (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-B16, PMID: 31015346).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03592264 Phase Ib/II OBI-3424 This Study is to Evaluate OBI-3424 Safe and Effective Treatment Dose in Subjects With Hepatocellular Carcinoma or Castrate Resistant Prostate Cancer Terminated USA 0
NCT04315324 Phase II OBI-3424 Study to Test AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) Recruiting USA 0


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