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Therapy Name Omburtamab I-131
Synonyms
Therapy Description

Omburtamab I-131 is a radiolabeled monoclonal antibody that targets the glycoprotein B7-H3 (CD276), potentially resulting in increased tumor cell death (PMID: 30879172).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Omburtamab I-131 Iodine I 131 MOAB 8H9|Iodine I 131 Omburtamab CD276 Antibody 16 Omburtamab I-131 is a radiolabeled monoclonal antibody that targets the glycoprotein B7-H3 (CD276), potentially resulting in increased tumor cell death (PMID: 30879172).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05064306 Expanded access Omburtamab I-131 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults Available USA 0
NCT00089245 Phase I Omburtamab I-131 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer Terminated USA 0
NCT03275402 Phase II Omburtamab I-131 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases Terminated USA | ESP | DNK 1
NCT04743661 Phase II Bevacizumab + Irinotecan + Omburtamab I-131 + Temozolomide Omburtamab I-131 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Active, not recruiting USA 0


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