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Therapy Name IMG-7289
Synonyms
Therapy Description

IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IMG-7289 IMG7289|IMG 7289|Bomedemstat KDM1A Inhibitor 15 IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F myeloproliferative neoplasm sensitive IMG-7289 Preclinical Actionable In a preclinical study, IMG-7289 treatment led to decreased JAK2 V617F allele burden in peripheral blood cells and splenic cells, decreased spleen size, and improved survival in a transgenic mouse model of myeloproliferative neoplasm expressing JAK2 V617F (PMID: 31723778). 31723778
JAK2 V617F TP53 R248W acute myeloid leukemia predicted - sensitive IMG-7289 Preclinical - Cell culture Actionable In a preclinical study, IMG-7289 treatment led to inhibition of colony formation, increased apoptosis and induction of cell cycle arrest in an acute myeloid leukemia cell line harboring JAK2 V617F and TP53 R248W in culture (PMID: 31723778). 31723778
JAK2 V617F hematologic cancer predicted - sensitive IMG-7289 Preclinical - Cell culture Actionable In a preclinical study, IMG-7289 treatment led to increased apoptosis induction in transformed cells expressing JAK2 V617F compared to cells expressing wild-type Jak2 in culture (PMID: 31723778). 31723778

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06351631 Phase III IMG-7289 A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) Recruiting USA | NZL | ITA | GBR | AUS 1
NCT04262141 Phase II IMG-7289 IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV) Active, not recruiting USA 0
NCT03136185 Phase II IMG-7289 IMG-7289 in Patients With Myelofibrosis Completed USA | ITA | GBR | DEU | AUS 0
NCT05223920 Phase II IMG-7289 Extension Study of Bomedemstat (IMG-7289) in Patients With Myeloproliferative Neoplasms Completed USA | NZL | ITA | GBR | DEU | AUS 1
NCT05558696 Phase II IMG-7289 Bomedemstat in Patients With Polycythemia Vera Active, not recruiting USA | GBR | AUS 0


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