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Therapy Name	IMG-7289
Synonyms
Therapy Description	IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
IMG-7289		IMG7289\|IMG 7289\|Bomedemstat	KDM1A Inhibitor 15	IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
JAK2 V617F	hematologic cancer	predicted - sensitive	IMG-7289	Preclinical - Cell culture	Actionable	In a preclinical study, IMG-7289 treatment led to increased apoptosis induction in transformed cells expressing JAK2 V617F compared to cells expressing wild-type Jak2 in culture (PMID: 31723778).	31723778
JAK2 V617F TP53 R248W	acute myeloid leukemia	predicted - sensitive	IMG-7289	Preclinical - Cell culture	Actionable	In a preclinical study, IMG-7289 treatment led to inhibition of colony formation, increased apoptosis and induction of cell cycle arrest in an acute myeloid leukemia cell line harboring JAK2 V617F and TP53 R248W in culture (PMID: 31723778).	31723778
JAK2 V617F	myeloproliferative neoplasm	sensitive	IMG-7289	Preclinical	Actionable	In a preclinical study, IMG-7289 treatment led to decreased JAK2 V617F allele burden in peripheral blood cells and splenic cells, decreased spleen size, and improved survival in a transgenic mouse model of myeloproliferative neoplasm expressing JAK2 V617F (PMID: 31723778).	31723778

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04262141	Phase II	IMG-7289	IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)	Active, not recruiting	USA	0
NCT05558696	Phase II	IMG-7289	Bomedemstat in Patients With Polycythemia Vera	Active, not recruiting	USA \| GBR \| AUS	0
NCT03136185	Phase II	IMG-7289	IMG-7289 in Patients With Myelofibrosis	Completed	USA \| ITA \| GBR \| DEU \| AUS	0
NCT05223920	Phase II	IMG-7289	Extension Study of Bomedemstat (IMG-7289) in Patients With Myeloproliferative Neoplasms	Completed	USA \| NZL \| ITA \| GBR \| DEU \| AUS	1
NCT06351631	Phase III	IMG-7289	A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)	Recruiting	USA \| NZL \| ITA \| GBR \| AUS	1

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