Therapy Detail
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| Therapy Name | IMG-7289 |
| Synonyms | |
| Therapy Description |
IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| IMG-7289 | IMG7289|IMG 7289|Bomedemstat | KDM1A Inhibitor 15 | IMG-7289 irreversibly inhibits lysine-specific demethylase 1 (KDM1A, LSD1), resulting in growth inhibition of hematopoietic cells (PMID: 29453291, PMID: 31801559). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F | hematologic cancer | predicted - sensitive | IMG-7289 | Preclinical - Cell culture | Actionable | In a preclinical study, IMG-7289 treatment led to increased apoptosis induction in transformed cells expressing JAK2 V617F compared to cells expressing wild-type Jak2 in culture (PMID: 31723778). | 31723778 |
| JAK2 V617F | myeloproliferative neoplasm | sensitive | IMG-7289 | Preclinical | Actionable | In a preclinical study, IMG-7289 treatment led to decreased JAK2 V617F allele burden in peripheral blood cells and splenic cells, decreased spleen size, and improved survival in a transgenic mouse model of myeloproliferative neoplasm expressing JAK2 V617F (PMID: 31723778). | 31723778 |
| JAK2 V617F TP53 R248W | acute myeloid leukemia | predicted - sensitive | IMG-7289 | Preclinical - Cell culture | Actionable | In a preclinical study, IMG-7289 treatment led to inhibition of colony formation, increased apoptosis and induction of cell cycle arrest in an acute myeloid leukemia cell line harboring JAK2 V617F and TP53 R248W in culture (PMID: 31723778). | 31723778 |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05558696 | Phase II | IMG-7289 | Bomedemstat in Patients With Polycythemia Vera | Active, not recruiting | USA | GBR | AUS | 0 |
| NCT05223920 | Phase II | IMG-7289 | Extension Study of Bomedemstat (IMG-7289) in Patients With Myeloproliferative Neoplasms | Completed | USA | NZL | ITA | GBR | DEU | AUS | 1 |
| NCT03136185 | Phase II | IMG-7289 | IMG-7289 in Patients With Myelofibrosis | Completed | USA | ITA | GBR | DEU | AUS | 0 |
| NCT06351631 | Phase III | IMG-7289 | A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) | Recruiting | USA | NZL | ITA | GBR | AUS | 1 |
| NCT04262141 | Phase II | IMG-7289 | IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV) | Active, not recruiting | USA | 0 |
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