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Therapy Name SAR408701
Synonyms
Therapy Description

SAR408701 is an anti-CEACAM5 antibody in conjugation with DM4, which may lead to specific toxicity towards CEACAM5-expressing tumor cells (Eu J Cancer Dec 2016, 69(Suppl 1):S14-S15).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR408701 SAR-408701|Tusamitamab ravtansine CEACAM5 Antibody 8 SAR408701 is an anti-CEACAM5 antibody in conjugation with DM4, which may lead to specific toxicity towards CEACAM5-expressing tumor cells (Eu J Cancer Dec 2016, 69(Suppl 1):S14-S15).

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05245071 Phase II SAR408701 Tusamitamab Ravtansine in NSQ NSCLC Participants With Negative or Moderate CEACAM5 Expression Tumors and High Circulating CEA (CARMEN-LC06) Active, not recruiting USA | TUR | ITA | FRA | ESP | BEL 1
NCT05703555 Phase II SAR408701 INTRUSION: Unraveling the INTRatUmoral PK/PD relatION for SAR408701 (INTRUSION) Withdrawn NLD 0
NCT04659603 Phase II SAR408701 Gemcitabine + SAR408701 Tusamitamab Ravtansine Monotherapy and in Combination in Patients With CEACAM5-positive Advanced Solid Tumors (CARMEN-BT01) Active, not recruiting USA | TUR | NLD | HUN | ESP | ARG 4
NCT05429762 Phase I SAR408701 Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors (TusaRav-QT) Terminated USA | TUR | FRA | ESP | BEL 0
NCT02187848 Phase Ib/II SAR408701 Evaluation of SAR408701 in Patients With Advanced Solid Tumors Terminated USA | FRA | ESP | CAN 1
NCT04154956 Phase III SAR408701 Docetaxel SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients (CARMEN-LC03) Active, not recruiting USA | TUR | ROU | POL | NLD | LTU | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BGR | BEL | AUS | ARG 9


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