Therapy Detail
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| Therapy Name | PF-06801591 |
| Synonyms | |
| Therapy Description |
PF-06801591 (sasanlimab) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32847983). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PF-06801591 | PF06801591|PF 06801591|Sasanlimab | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | PF-06801591 (sasanlimab) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32847983). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 over exp | Advanced Solid Tumor | predicted - sensitive | PF-06801591 | Phase I | Actionable | In a Phase I trial, treatment with PF-06801591 resulted in a greater overall objective response in patients with an advanced solid tumor and higher CD274 expression (n=10), including four partial responses and two patients with stable disease, compared to those patients with lower CD274 expression (n=20), which included one partial response and ten patients with stable disease (PMID: 31145415; NCT02573259). | 31145415 |
| CD274 over exp | lung non-small cell carcinoma | predicted - sensitive | PF-06801591 | Phase Ib/II | Actionable | In Phase Ib/II trial, PF-06801591 (sasanlimab) therapy was well tolerated in patients with locally advanced or metastatic non-small cell lung cancer and resulted in an objective response rate (ORR) of 16.4% (11/67, 11 partial responses), disease control rate of 56.7% (38/67), median progression-free survival of 3.7 months, and median overall survival of 14.7 months, with an ORR of 36.4% (4/11) in patients with high CD274 (PD-L1) expression (>/=50%) (PMID: 37385154; NCT02573259). | 37385154 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02573259 | Phase I | PF-06801591 | A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors | Completed | USA | POL | BGR | 4 |
| NCT06623162 | Phase II | PF-06801591 Cisplatin + Gemcitabine | Sasanlimab As Maintenance Treatment Based on Clinical Response to Neoadjuvant Treatment in Molecularly Categorized Muscle Invasive Bladder Cancer Patients (SASAN-SPARING) | Not yet recruiting | ESP | 0 |
| NCT05241340 | Phase II | PF-06801591 | Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer (RAD-VACCINE) | Recruiting | USA | 0 |
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