Therapy Detail
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| Therapy Name | INT230-6 |
| Synonyms | |
| Therapy Description |
INT230-6 is a therapy comprised of cisplatin and vinblastine plus a cell penetration excipient, which leads to improved uptake of the drug into cancer cells, potentially resulting in tumor regression as well as indirect antitumor effects (Cancer Res 2015;75(15 Suppl):Abstract nr 4295, PMID: 31646070). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| INT230-6 | INT 230-6|INT-230-6 | INT230-6 is a therapy comprised of cisplatin and vinblastine plus a cell penetration excipient, which leads to improved uptake of the drug into cancer cells, potentially resulting in tumor regression as well as indirect antitumor effects (Cancer Res 2015;75(15 Suppl):Abstract nr 4295, PMID: 31646070). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03058289 | Phase Ib/II | INT230-6 INT230-6 + unspecified PD-1 antibody | A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 (IT-01) | Completed | USA | CAN | 0 |
| NCT04781725 | Phase II | INT230-6 | Intratumoral INT230-6 in Breast Cancer | Unknown status | CAN | 0 |
| NCT06263231 | Phase III | Eribulin Trabectedin Pazopanib INT230-6 | A Study to Investigate Efficacy & Safety of INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3) (INVINCIBLE-3) | Recruiting | USA | 0 |
| NCT06358573 | Phase II | INT230-6 Cyclophosphamide + Doxorubicin + Pembrolizumab Pembrolizumab Carboplatin + Paclitaxel + Pembrolizumab Cyclophosphamide + Epirubicin + Pembrolizumab | Intratumoral INT230-6 Followed by Neoadjuvant Immuno-chemotherapy in Patients With Early TNBC. INVINCIBLE-4-SAKK | Recruiting | CHE | 0 |
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