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Therapy Name	FN-1501
Synonyms
Therapy Description	FN-1501 inhibits FLT3, CDK2, CDK4, and CDK6, resulting in decreased downstream signaling and potentially leading to reduced tumor cell proliferation and tumor growth (PMID: 29357250).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
FN-1501		FN1501\|FN 1501	CDK2 Inhibitor 31 CDK4 Inhibitor 17 CDK6 Inhibitor 6 FLT3 Inhibitor 69	FN-1501 inhibits FLT3, CDK2, CDK4, and CDK6, resulting in decreased downstream signaling and potentially leading to reduced tumor cell proliferation and tumor growth (PMID: 29357250).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	leukemia	sensitive	FN-1501	Preclinical - Cell line xenograft	Actionable	In a preclinical study, treatment with FN-1501 reduced phoshorylation of FLT3 and downstream STAT5, ERK, and AKT, induced apoptosis and cell-cycle arrest, and decreased proliferation in a human leukemia cell line harboring a FLT3-ITD mutation in culture, and induced tumor regression in xenograft models (PMID: 29357250).	29357250

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03690154	Phase I	FN-1501	Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Anti-tumor Activity of FN-1501 Monotherapy in Patients With Advanced Solid Tumors	Terminated	USA \| AUS	0

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