Therapy Detail
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| Therapy Name | Genistein |
| Synonyms | |
| Therapy Description |
Genistein binds to protein tyrosine kinase, inhibiting downstream signaling and promoting differentiation, and also inhibits topoisomerase leading to cell cycle arrest and apoptosis (PMID: 32486630). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Genistein | CI 75610|Prunetol|Genisteol | Genistein binds to protein tyrosine kinase, inhibiting downstream signaling and promoting differentiation, and also inhibits topoisomerase leading to cell cycle arrest and apoptosis (PMID: 32486630). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02624388 | Phase II | Genistein | Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) | Terminated | USA | 0 |
| NCT01985763 | Phase Ib/II | Genistein Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab | Genistein in Treatment of Metastatic Colorectal Cancer | Completed | USA | 0 |
| NCT02766478 | Phase II | Genistein | Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer | Terminated | USA | 0 |
| NCT01489813 | Phase II | Genistein | Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment | Active, not recruiting | USA | 0 |
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