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Therapy Name Mivavotinib + Paclitaxel
Synonyms
Therapy Description

TAK-659 is an inhibitor of spleen tyrosine kinase (SYK), which may lead to B-cell inhibition and antitumor activity (http://meetinglibrary.asco.org/content/134551-144).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Mivavotinib TAK-659|TAK659 SYK Inhibitor 15 Mivavotinib (TAK-659) is an inhibitor of spleen tyrosine kinase (SYK), which may lead to B-cell inhibition and antitumor activity (PMID: 32327472).
Paclitaxel Taxol 7-Epipaclitaxel Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03756818 Phase I Mivavotinib + Paclitaxel TAK-659 and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed USA 0


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