Therapy Detail

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Therapy Name	GRT-C901 + GRT-R902 + Ipilimumab + Nivolumab
Synonyms
Therapy Description	GRT-C901 is a personalized priming cancer vaccine that encodes patient tumor-specific neoantigens, potentially resulting in increased anti-tumor immune response against neoantigen-expressing tumor cells (NCI Drug Dictionary).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
GRT-C901		GRTC901\|GRT C901		GRT-C901 is a personalized priming cancer vaccine that encodes patient tumor-specific neoantigens, potentially resulting in increased anti-tumor immune response against neoantigen-expressing tumor cells (NCI Drug Dictionary).
GRT-R902		mRNA-based TSNA boosting vaccine GRT-R902\|GRTR902\|GRT R902		GRT-R902 is a personalized boosting cancer vaccine comprising mRNA for patient tumor-specific neoantigens, potentially resulting in increased anti-tumor immune response against neoantigen-expressing tumor cells (NCI Drug Dictionary).
Ipilimumab	Yervoy	BMS-734016	CTLA4 Antibody 33 Immune Checkpoint Inhibitor 149	Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).
Nivolumab	Opdivo	MDX-1106\|BMS-936558	Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124	Opdivo (nivolumab) is an antibody that targets PD-1 (PDCD1), which results in increased T-cell activation and enhanced anti-tumor immune response (PMID: 28891423). Opdivo (nivolumab) is FDA approved for use as a monotherapy in patients with non-small cell lung cancer (NSCLC) progressed on prior therapies, Hodgkin's lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma (UC) , esophageal squamous cell carcinoma, resected esophageal or gastroesophageal junction (GEJ) cancer, as a monotherapy or in combination with Yervoy (ipilimumab) for melanoma, renal cell carcinoma (RCC), microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (including patients 12 years or older), and hepatocellular carcinoma, in combination with Yervoy (ipilimumab) as first-line therapy for PD-L1-positive (>=1%) metastatic NSCLC without EGFR or ALK alterations, with Yervoy (ipilimumab) and platinum-based chemotherapy as first-line therapy for metastatic or recurrent NSCLC without EGFR or ALK alterations, with platinum doublet chemotherapy as neoadjuvant treatment for patients with resectable NSCLC, with Cabometyx (cabozantinib) for advanced RCC, with fluoropyrimidine- and platinum-containing chemotherapy for advanced or metastatic gastric cancer, GEJ cancer, and esophageal adenocarcinoma, and with cisplatin and gemcitabine as first-line treatment for unresectable or metastatic UC (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03639714	Phase Ib/II	GRT-C901 + GRT-R902 + Ipilimumab + Nivolumab	A Study of a Personalized Neoantigen Cancer Vaccine	Completed	USA \| AUS	0

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