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Therapy Name pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab
Synonyms
Therapy Description

Pp65 dendritic cell vaccine is a cancer vaccine composed of autologous dendritic cells modified to express pp65, which potentially results in increased immune response against pp65-expressing tumors (PMID: 25762141, PMID: 28411277).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Temozolomide Temodar Methazolastone|TMZ Chemotherapy - Alkylating 18 Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary).
Varlilumab CDX-1127|CDX127 CD27 Antibody 3 Varlilumab (CDX-1127) is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397, PMID: 32380537).
pp65 Dendritic Cell Vaccine pp65 DC Vaccine Pp65 dendritic cell vaccine is a cancer vaccine composed of autologous dendritic cells modified to express pp65, which potentially results in increased immune response against pp65-expressing tumors (PMID: 25762141, PMID: 28411277).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03688178 Phase II pp65 Dendritic Cell Vaccine + Temozolomide pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab (DERIVe) Active, not recruiting USA 0


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