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Therapy Name Pimivalimab
Synonyms
Therapy Description

Pimivalimab (JTX-4014) is a monoclonal antibody that targets PD-1 (PDCD1), potentially resulting in restoration of anti-tumor immune response (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Pimivalimab JTX4014|JTX 4014|JTX-4014 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 Pimivalimab (JTX-4014) is a monoclonal antibody that targets PD-1 (PDCD1), potentially resulting in restoration of anti-tumor immune response (NCI Drug Dictionary).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 over exp pleomorphic adenoma carcinoma predicted - sensitive Pimivalimab Case Reports/Case Series Actionable In a Phase I trial, Pimivalimab (JTX-4014) treatment led to a partial response that was ongoing for at least 386 days in a patient with CD274 (PD-L1)-positive (100% staining) carcinoma ex-pleomorphic adenoma (PMID: 32989552; NCT03790488). 32989552
CD274 positive ovarian cancer predicted - sensitive Pimivalimab Case Reports/Case Series Actionable In a Phase I trial, Pimivalimab (JTX-4014) treatment led to a partial response lasting 232 days in a patient with CD274 (PD-L1)-positive (5% staining) ovarian cancer (PMID: 32989552; NCT03790488). 32989552
CD274 positive mucoepidermoid carcinoma predicted - sensitive Pimivalimab Case Reports/Case Series Actionable In a Phase I trial, Pimivalimab (JTX-4014) treatment led to a complete response that was ongoing for at least 338 days in a patient with CD274 (PD-L1)-positive (60% staining) mucoepidermoid carcinoma of the parotid (PMID: 32989552; NCT03790488). 32989552

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03790488 Phase I Pimivalimab Study of a PD-1 Inhibitor (JTX-4014) in Subjects With Solid Tumor Malignancies Completed USA 0


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