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Therapy Name Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine
Synonyms
Therapy Description

Anti-BCMA CAR T Cells are T-cells that express a chimeric antigen receptor targeting B-cell maturation antigen (BCMA), which may induce an enhanced anti-tumor immune response against BCMA-expressing tumor cells (PMID: 23344265).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-BCMA CAR-T cells CART-BCMA|CT053 Anti-BCMA CAR-T cells are T-cells engineered to express a chimeric antigen receptor (CAR) targeting BCMA, which may enhance antitumor immune response (PMID: 23344265).
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Fludarabine Fludara FAMP|Fludarabine phosphate Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03602612 Phase I Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine T Cells Expressing a Novel Fully-Human Anti-BCMA CAR for Treating Multiple Myeloma Active, not recruiting USA 0
NCT05577000 Phase I Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma Active, not recruiting USA 0


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