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Therapy Detail
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| Therapy Name | GSK3745417 |
| Synonyms | |
| Therapy Description |
GSK3745417 is an agonist to stimulator of interferon genes (STING, TMEM173), which activates the immune system by stimulating cells in the tumor microenvironment (PMID: 31355488). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GSK3745417 | GSK-3745417|GSK 3745417 | STING1 Agonist 19 | GSK3745417 is an agonist to stimulator of interferon genes (STING, TMEM173), which activates the immune system by stimulating cells in the tumor microenvironment (PMID: 31355488). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05424380 | Phase I | GSK3745417 | A Phase 1, Open Label Study of Intravenous GSK3745417 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Determine RP2D & Schedule in Participants With Relapsed or Refractory Myeloid Malignancies Including AML and HR MDS | Terminated | NLD | ITA | ESP | DEU | CAN | 0 |
| NCT03843359 | Phase I | GSK3745417 GSK3745417 + Pembrolizumab | Phase 1 First Time in Humans (FTIH), Open Label Study of GSK3745417 Administered to Subjects With Advanced Solid Tumors | Active, not recruiting | USA | NLD | FRA | ESP | CAN | AUS | 2 |
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