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Therapy Name	Durvalumab + Exemestane
Synonyms
Therapy Description	Aromasin (exemestane) is an aromatase inhibitor, which prevents the conversion of androgenic precursors to estrogens (NCI Drug Dictionary).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Durvalumab	Imfinzi	MEDI4736	Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 129	Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA-approved for use in patients with unresectable, stage III non-small cell lung cancer, and limited-stage small cell lung cancer, in combination with Imjudo (tremelimumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations, in combination with platinum-based chemotherapy as neoadjuvant therapy followed by surgery and adjuvant Imfinzi (durvalumab) in patients with resectable non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer, in combination with Imjudo (tremelimumab) in adult patients with unresectable hepatocellular carcinoma, in combination with carboplatin plus paclitaxel followed by single-agent Imfinzi (durvalumab) in adult patients with mismatch repair deficient endometrial cancer, in combination with cisplatin plus gemcitabine followed by single-agent Imfinzi (durvalumab) in adult patients with muscle invasive bladder cancer (FDA.gov).
Exemestane	Aromasin		Aromatase Inhibitor 3	Aromasin (exemestane) is an aromatase inhibitor, which prevents the conversion of androgenic precursors to estrogens (NCI Drug Dictionary).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03874325	Phase II	Durvalumab + Exemestane Durvalumab + Letrozole Anastrozole + Durvalumab	Aromatase Inhibitor and Durvalumab in Postmenopausal Breast Cancer	Terminated	USA	0

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