Therapy Detail
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| Therapy Name | Lemzoparlimab |
| Synonyms | |
| Therapy Description |
Lemzoparlimab (TJ011133) is a monocloncal antibody targeting CD47, which blocks the interaction of CD47 with SIRPA to enhance macrophage mediated phagocytosis of tumor cells (Blood (2019) 134 (Supplement_1): 4063). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Lemzoparlimab | TJC4|TJ 011133|TJ-011133|TJ011133 | CD74 Antibody 3 | Lemzoparlimab (TJ011133) is a monocloncal antibody targeting CD47, which blocks the interaction of CD47 with SIRPA to enhance macrophage mediated phagocytosis of tumor cells (Blood (2019) 134 (Supplement_1): 4063). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04895410 | Phase I | Lemzoparlimab Dexamethasone + Lemzoparlimab Daratumumab + Dexamethasone + Lemzoparlimab Carfilzomib + Dexamethasone + Lemzoparlimab Dexamethasone + Lemzoparlimab + Pomalidomide | Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Lemzoparlimab (TJ011133) With or Without Oral/IV Dexamethasone and in Combination With Oral/IV/Subcutaneous Anti-Myeloma Regimens in Adult Participants With Multiple Myeloma | Terminated | USA | ISR | FRA | ESP | DEU | AUS | 1 |
| NCT03934814 | Phase I | Lemzoparlimab Lemzoparlimab + Pembrolizumab Lemzoparlimab + Rituximab | Study of TJ011133 Subjects With Relapsed/Refractory Advanced Solid Tumors and Lymphoma | Completed | USA | 1 |
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