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Therapy Detail
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| Therapy Name | Denosumab + Radium Ra 223 dichloride |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Denosumab | Xgeva | AMG162|AMG-162|AMG 162|Prolia | Xgeva (denosumab) is an antibody that binds to RANKL protein, inhibiting osteoclast activity and is FDA approved for use in patients with giant cell tumor of the bone (FDA.gov). | |
| Radium Ra 223 dichloride | Xofigo | BAY 88-8223|alpharadin|BAY88-8223|Radium 223 Dichloride | Radium Ra 223 dichloride is a radium-based radiopharmaceutical that targets bone via incorporation into bony matrix, and results in DNA double strand breaks and tumor regression in bone (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02366130 | Phase II | Tamoxifen Denosumab + Radium Ra 223 dichloride Fulvestrant | Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer | Completed | USA | 0 |
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