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| Therapy Name | hu14.18-IL2 |
| Synonyms | |
| Therapy Description |
Hu14.18-IL2 (Lorukafusp alfa) is a fusion protein comprised of a monoclonal antibody targeting the GD2 disialoganglioside linked to interleukin-2, which may inhibit growth of and induce an immune response against GD2-expressing tumors (PMID: 22844125, PMID: 20921469, PMID: 30073390). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| hu14.18-IL2 | Lorukafusp alfa|EMD-273063|EMD 273063|APN301|APN-301|APN 301 | Hu14.18-IL2 (Lorukafusp alfa) is a fusion protein comprised of a monoclonal antibody targeting the GD2 disialoganglioside linked to interleukin-2, which may inhibit growth of and induce an immune response against GD2-expressing tumors (PMID: 22844125, PMID: 20921469, PMID: 30073390). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03209869 | Phase I | hu14.18-IL2 | Treatment of Relapsed or Refractory Neuroblastoma With Expanded Haploidentical NK Cells and Hu14.18-IL2 | Withdrawn | USA | 0 |
| NCT03958383 | Phase Ib/II | hu14.18-IL2 hu14.18-IL2 + Nivolumab hu14.18-IL2 + Ipilimumab + Nivolumab | IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma | Active, not recruiting | USA | 0 |
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