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Therapy Name Sunvozertinib
Synonyms
Therapy Description

Sunvozertinib (DZD9008) is an irreversible EGFR inhibitor that preferentially inhibits mutant EGFR and ERBB2 (HER2), which may lead to growth inhibition of tumor cells with EGFR activation (AACR Annual Meeting 2019, Abstract 3081, PMID: 35404393).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Sunvozertinib DZD9008|DZD-9008|DZD 9008 EGFR Inhibitor (Pan) 62 HER2 Inhibitor 42 Sunvozertinib (DZD9008) is an irreversible EGFR inhibitor that preferentially inhibits mutant EGFR and ERBB2 (HER2), which may lead to growth inhibition of tumor cells with EGFR activation (AACR Annual Meeting 2019, Abstract 3081, PMID: 35404393).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03974022 Phase Ib/II Sunvozertinib Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1) Active, not recruiting USA | ITA | FRA | ESP | CAN | AUS | ARG 6
NCT05668988 Phase III Sunvozertinib Carboplatin + Pemetrexed Disodium A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28) Recruiting USA | TUR | POL | NLD | ITA | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 1


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