Therapy Detail
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| Therapy Name | AVB-S6-500 + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AVB-S6-500 | AVBS6500|AV S6 500|Batiraxcept|AVB-500|RUGA-S6 | AVB-S6-500 is a fusion protein comprised of human IgG1 linked to the extracellular domain of Axl, which binds to growth arrest-specific protein 6 (GAS6), potentially resulting in decreased downstream signaling and reduced tumor growth (PMID: 32148495, PMID: 31599479). | ||
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04729608 | Phase III | AVB-S6-500 + Paclitaxel Paclitaxel | Study of AVB-S6-500 in Combination With Paclitaxel vs Paclitaxel in Patients With Platinum-Resistant Recurrent Ovarian Cancer | Terminated | USA | POL | ITA | GBR | FRA | ESP | CZE | CAN | BEL | 2 |
| NCT03639246 | Phase Ib/II | AVB-S6-500 + Paclitaxel AVB-S6-500 + Pegylated liposomal doxorubicin Paclitaxel Pegylated liposomal doxorubicin | Efficacy and Safety Study of AVB-S6-500 in Patients With Platinum-Resistant Recurrent Ovarian Cancer | Completed | USA | 0 |
| NCT05826015 | Phase I | AVB-S6-500 AVB-S6-500 + Paclitaxel | AVB-500 (Batiraxcept) in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer | Withdrawn | 0 |
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